12/30/2023 0 Comments Weed depersonalization![]() ![]() Descriptive and psychometric assessments only allow to comment on the absence or the presence of this phenomenon, but do not capture the origins and the meaning of social avoidance. Especially in the absence of any other clinically relevant phenomena, understanding the origins of social avoidance may be one the most challenging tasks in assessing whether adolescents and young adults are at risk for developing schizophrenia. Social avoidance in young patients is a clinically worrisome phenomenon that characterizes impending schizophrenia, but that also constitutes a core phenomenon in avoidant personality disorder (AvPD), schizoid personality disorder (ScPD), and in autism spectrum disorder (ASD). Our findings of the potential stimulation targets might help clinicians optimize the application of non-invasive brain stimulation therapy in individuals with DPD. We identified several potential brain surface regions, including the bilateral medial prefrontal cortex, dorsal lateral prefrontal cortex, superior parietal gyrus, superior temporal gyrus, and right ventrolateral prefrontal cortex as potential sites. Potential targets were the 10-20 system coordinates for brain surface regions. We explored the potential brain surface regions from three pipelines: pipeline 1: activation likelihood estimation meta-analysis (five studies with 36 foci included) pipeline 2: functional connectivity analysis based on DPD-network (76 subjects included) and pipeline 3: functional connectivity analysis based on DPD regions of interest from the meta-analysis. The objective was to find potential locations for non-invasive brain stimulation on the depersonalization-derealization disorder. Exploring new stimulation locations via functional magnetic resonance imaging may improve the efficacy. However, the sites used in previous studies were empirical. Non-invasive brain stimulation seems to be beneficial for DPD patients.
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